منابع مشابه
Dendritic Spikes Veto Inhibition
How inhibition regulates dendritic excitability is critical to an understanding of the way neurons integrate the many thousands of synaptic inputs they receive. In this issue of Neuron, Müller et al. (2012) show that inhibition blocks the generation of weak dendritic spikes, leaving strong dendritic spikes intact.
متن کاملExtrasomatic spikes recorded from cat motoneurons. Possible dendritic spikes.
Extrasomatic (ES-) spikes were recorded in motoneurons in cats anesthetized with pentobarbital sodium and immobilized with d-tubocurarine. ES-spikes, 40-79 mV in amplitude, were distinguished from intrasomatic spikes by their differences in responses to a train of 8 pulses at 500 Hz given to the L 7 or S 1 ventral root. In 23 motoneurons 3-6 different spikes could be recorded from the same site...
متن کاملDendritic Spikes in Sensory Perception
What is the function of dendritic spikes? One might argue that they provide conditions for neuronal plasticity or that they are essential for neural computation. However, despite a long history of dendritic research, the physiological relevance of dendritic spikes in brain function remains unknown. This could stem from the fact that most studies on dendrites have been performed in vitro. Fortun...
متن کاملDendritic spikes induce single-burst long-term potentiation.
The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong acti...
متن کاملField potentials generated by dendritic spikes and synaptic potentials.
Predictions from the cable model and equations for field potentials generated by single neurons are computed and compared with extra cellular recordings from synaptically activated cerebellar Purkinje cell dendrites. Neither theory predicts the results, nor does the expermental situation satisfy the assumptions of either theory. Theoretical calculations from a recent formulation developed by Ra...
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ژورنال
عنوان ژورنال: Science
سال: 1969
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.166.3905.637